Chemicals Alectinib supplier and solvents were reagent grade and used without further purification. The homogeneity of the compounds CSF-1R inhibitor was checked using precoated TLC plates (E.Merk Kieselgel 60 F254). 2-Iodoaniline (1) (0.1 mmol), oxthiocyanate (0.15 mmol) and a few drops of DMF and FeCl3 were irradiated under microwave for 2–3 min. After the completion of reaction, it was poured

onto ice and product was extracted from ethyl acetate. IR (cm−1) 3468, 1627; 1H NMR δ = 7.13–7.19 (m, 2H), 7.32 (t, 1H), 7.41 (t, 2H), 7.50 (d, 2H), 7.56 (d, 1H), 7.63 (d, 1H). 1H NMR δ = 3.74 (s, 3H), 6.85 (d, 2H), 6.98 (t, 1H), 7.42 (t, 1H), 7.42–7.12 (m, 3H), 7.42 (d, 1H). 1H NMR δ = 7.14–7.11 (m, 3H), 7.42 (t, 1H), 7.42 (d, 1H), 7.64–7.85 (m, 3H), 10.41 (br, 1H). 1H NMR δ = 7.19 (t, 1H), 7.24 (d, 1H), 7.74 (d, MRIP 2H), 7.62 (d, 1H), 7.85 (d, 2H). 1H NMR δ = 7.42–7.20

(m, 2H), 7.15 (t, 1H), 7.24 (t, 2H), 7.85 (d, 2H), 7.66 (d, 1H), 7.64 (d, 1H). 1H NMR δ = 3.84 (s, 3H), 6.87 (d, 2H), 7.10 (t, 1H), 7.54 (t, 1H), 7.22–7.44 (m, 3H), 7.62 (d, 1H). 1H NMR δ = 7.14–7.77 (m, 3H), 7.24 (t, 1H), 7.22 (d, 1H), 7.15–7.21 (m, 3H), 10.14 (brs, 1H). 1H NMR δ = 7.12 (t, 1H), 7.41 (d, 1H), 7.74 (d, 2H), 7.52 (d, 1H), 7.42 (d, 2H). 1H NMR δ = 7.13–7.19 (m, 2H), 7.32 (t, 1H), 7.41 (t, 2H), 7.50 (d, 2H), 7.56 (d, 1H), 7.63 (d, 1H). 1H NMR δ = 3.84 (s, 3H), 6.96 (d, 2H), 7.09 (t, 1H), 7.27 (t, 1H), 7.38–7.44 (m, 3H), 7.57 (d, 1H). 1H NMR δ = 7.11–7.14 (m, 3H), 7.54 (t, 1H), 7.24 (d, 1H), 7.24–7.44 (m, 3H), 10.40 (br, 1H). 1H NMR δ = 7.11 (t, 1H), 7.21 (d, 1H), 7.22 (d, 2H), 7.41 (d, 1H), 7.65 (d, 2H). 1H NMR δ = 7.13–7.19 (m, 2H), 7.32 (t, 1H), 7.41 (t, 2H), 7.50 (d, 2H), 7.56 (d, 1H), 7.63 (d, 1H). 1H NMR δ = 3.82 (s, 3H), 6.89 (d, 2H), 7.11 (t, 1H), 7.42 (t, 1H), 7.41–7.41 (m, 3H), 7.14 (d, 1H). 1H NMR δ = 7.41–7.14 (m, 3H), 7.54 (t, 1H), 7.34 (d, 1H), 7.24–7.42 (m, 3H), 10.24 (br, 1H). 1H NMR δ = 7.41 (t, 1H), 7.41 (d, 1H), 7.12 (d, 2H), 7.53 (d, 1H), 6.93 (d, 2H). I have developed an efficient protocol for the synthesis and characterization of 6-substituted-N-arylbenzo[d]oxazol-2-amines. Operational simplicity, cleaner reaction, easer work-up and are environmentally co-friendly reactions compared to other methods.