\n\nConclusions: There are alternatives GW786034 to clonazepam therapy for RBD which can be as effective and may be better tolerated.”
“Background: During preoperative radiotherapy, effective doses of ionizing radiation occasionally cause wound complications after subsequent surgery. This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. Material & Methods: Forty Wistar albino rats were randomized into four groups containing 10 rats each. A 3 cm long surgical full-thickness midline

laparotomy was performed to all groups (Groups 1-4). Group 1 was designed as a control group without radiation therapy and NAC treatment. Groups 2, 3 and 4 received a single abdominal dose of 10 Gy irradiation before laparotomy and groups 3 and 4 received oral and intraperitoneal NAC, respectively. Results: Group comparisons demonstrated that breaking strength was significantly

higher in NAC treated rats. A statistically significant difference was determined in terms of superoxide dismutase (SOD), Vactosertib mouse malondealdehyde (MDA) and glutation (GSH) values between groups (p smaller than 0.001). Nevertheless, advanced oxidation protein products (AOPP) levels were found to be similar between groups (p=0.163). Serum GSH and SOD levels were significantly higher in groups 3 and 4 when compared to group 2 (p smaller than 0.05). Similarly, there was a significant increase in serum MDA concentration, predicting lipid peroxidation, in group 2 when compared to groups 1, 3 and 4 (p smaller than 0.05). There was not a significant difference between

Groups 3 and 4 regarding GSH, MDA, SOD, and AOPP levels. Histopathological Birinapant analysis revealed that NAC administration, either orally or intraperitoneally, leads to a better incisional healing in terms of inflammation, granulation, collagen deposition, reepithelization and neovascularization. Conclusion: The present study supports the hypothesis that NAC administration alleviates the negative effects of radiotherapy on incisional wound healing by means of reducing oxidative stress markers and improving histologic parameters independent of the route of administration.”
“Objective:To evaluate the long-term effects of a progressive and specific balance group-based program in healthy elderly individuals with increased risk of falling. Design:Follow-up of a randomized controlled trial at nine and 15 months on a population that has previously been described at three months. Setting:The study was conducted in Stockholm, Sweden. Subjects:59 community-dwelling elderly (age 67-93 years), recruited by advertisement, were randomly allocated to training or to serve as controls. Intervention:Group balance training three times per week during 12 weeks with a 15 month follow-up time.

Factors uniquely associated with continuation decisions were parents’ socioeconomic status and ethnicity. The studies’ average methodological quality score was 10.6 (SD = 1.67; range, click here 8-14). Findings from this review can be useful in adapting and modifying guidelines for genetic counseling after prenatal diagnosis of a sex chromosome abnormality. Moreover, improving the quality of future studies on this topic may allow clearer understanding of the most influential factors affecting parental decisions.”
“The aim of the

present work is to investigate the anti-dermatophytic and cytotoxic activity of biosynthesized silver nanoparticles (AgNPs) using marine actinobacteria isolated from marine salterns soil. AgNPs were synthesized by mixing actinobacteria U0126 molecular weight culture supernatant with 1mM of AgNO3 and incubated at 28 degrees C under dark condition. The synthesized AgNPs are primarily confirmed by using UV, X-ray diffraction analysis and further characterized by AFM, Particle size analyzer and FESEM. The average

sizes of the synthesized nanoparticles were characterized using Bragg’s law and confirmed as 13.8 nm. The synthesized AgNPs showed anti-dermatophytic activity on Trichophyton rubrum (27 +/- 0.1 mm) and Trichophyton mentagrophytes (21 +/- 0.2 mm) cultures. The results of the MIC test reveal that T. rubrum (100 mu g/mL) is more sensitive to AgNPs than T. mentagrophytes (200 mu g/mL). The cytotoxicity effects of biosynthesized AgNPs were tested by brine shrimps assay and showed 75% of inhibition at the concentration of 25 mu g/mL and complete inhibition observed at high concentration of 50 to 100 mu g/mL.”
“Metabolomic

analysis of feces may provide insights on colorectal cancer (CRC) if assay performance is satisfactory. In lyophilized feces from 48 CRC cases, 102 matched controls, and 48 masked quality control specimens, 1043 small molecules were detected with a commercial platform. Assay reproducibility was good for 527 metabolites [technical intraclass selleck products correlation coefficient (ICC) bigger than 0.7 in quality control specimens], but reproducibility in 6-month paired specimens was lower for the majority of metabolites (within-subject ICC smaller than = 0.5). In the CRC cases and controls, significant differences (false discovery rate smaller than = 0.10) were found for 41 of 1043 fecal metabolites. Direct cancer association was found with three fecal heme-related molecules [covariate-adjusted 90th versus 10th percentile odds ratio (OR) = 17-345], 18 peptides/amino acids (OR = 3-14), palmitoyl-sphingomyelin (OR = 14), mandelate (OR = 3) and p-hydroxy-benzaldehyde (OR = 4). Conversely, cancer association was inverse with acetaminophen metabolites (OR smaller than 0.1), tocopherols (OR = 0.3), sitostanol (OR = 0.2), 3-dehydrocarnitine (OR = 0.4), pterin (OR = 0.3), conjugated-linoleate-18-2N7 (OR = 0.2), N-2-furoyl-glycine (OR = 0.

We conducted a validation study to compare QMR body composition analysis of 3 species of

bats (mass range 5.77-31.30 g) with traditional chemical extraction. In addition to scans of live animals, we tested the effectiveness of QMR for salvaged specimens (bats killed by wind turbines) and the effects of carcass temperature. Our analysis indicates that QMR body composition analysis is effective for live and salvaged animals. Frozen carcasses could not be analyzed, but results were not dramatically affected for specimens at 4 degrees C and 37 degrees C. QMR analysis eliminates the need to euthanize animals to determine body composition precisely, allows rapid and efficient data collection, and makes it possible to follow individuals longitudinally through time. DOI: 10.1644/10-MAMM-A-051.1.”
“This study HDAC inhibitors list was performed to determine the effect of injecting selenium into pregnant heifers at the last stage of gestation on the serum Se, Cu, Zn and Fe status of the heifers and their calves. Fifty Holstein heifers were randomly assigned to one of five treatments. Four and two weeks before the expected time of calving, the heifers were injected intramuscularly 10 ml (T1), 20 ml (T2), 30 click here ml (T3), 40 ml (T4) of selenium and vitamin E, respectively.

The control (C) group received no supplement. Each ml of the supplement c (Vet. Anim. Health BV) contained 0.5 mg Se as sodium selenite and 40 IU of D-L alphatocopheryl acetate. Blood samples were collected from heifers two weeks before the expected time of calving and on calving day. Blood samples of newborn calves also were taken from the jugular vein at birth and 7 days of age to measure the Se, Cu, Zn and Fe concentrations. The results indicated that the serum concentrations of Se increased in treated MLN8237 chemical structure heifers compared with the controls. The selenium concentrations were significantly increased in the colostrum of treated heifers (P < 0.05). Zn concentration of both serum and colostrum decreased in the treated group compared with

controls but it was not significantly different. Serum Se, Cu concentrations of calves of treated heifers increased during the first week of age but the serum concentration of Zn decreased in newborn calves at 7 days of age (P < 0.05). It seems that a high Se injection (T4) in pregnant heifers could increase the Cu and decrease the Zn concentrations and, thus, might disturb the Zn: Cu ratio which, in turn, leads to zinc reduction in heifers and their newborn calves. It can be concluded that a higher amount of Zn should be supplemented when more than 40 ml Se supplements are administered to pregnant heifers.”
“Action potential duration restitution (APDR) curves present spatial variations due to the electrophysiological heterogeneities present in the heart. Enhanced spatial APDR dispersion in ventricle has been suggested as an arrhythmic risk marker.

BRAF mutations occur along with greater shortening in HSP110T(17) during oncogenesis via the MSI pathway.”
“Excessive see more production of nitric oxide (NO) generated by inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of numerous inflammatory processes. The exact pathogenesis of denture-induced fibrous inflammatory hyperplasia (DIFIH) remains unclear The aim of this study was to assess iNOS expression in healthy oral mucosa (HOM) and DIFIH by immunohistochemical (IHC) method The expression of iNOS protein in HOM has been reported in numerous publications: particularly these tissues were

used as a control group. However there are some conflicting results whether healthy oral tissues express this website iNOS. In this study performing IHC method, DIFIH (n = 26) and HOM (n = 28) in formalin-fixed, paraffin-embedded sections were evaluated in terms of iNOS expression. The statistical analysis showed that there were

no significant differences between DIFIH and HOM regarding iNOS immunoreactivity (p>0.05). The results in this study indicate that iNOS does not have a determining role in pathogenesis of DIFIH. The constitutive iNOS expression in HOM under physiological conditions needs to be further evaluated”
“Background: Ten to fifteen percent of knee arthritis is reported to be isolated patellofemoral arthritis. Total knee arthroplasty is not recommended for isolated patella femoral arthritis particularly in young patients. We present the retrospective review of 45 consecutive patellofemoral replacements performed in 41 such patients, between June 2002 and January 2007.\n\nMaterials and Methods: All patients were operated by single surgeon (SM) or under his supervision. All forty five patients had minimum three year followup and had the data collected prospectively. No patient was lost to followup. This data was later collated by review of notes, radiographs, and a clinical followup. The patients were assessed using knee function score AP24534 cell line and Melbourne patellofemoral score.\n\nResults:

The average followup was 4.5 years. The preoperative average Melbourne (Bartlett) score was 10 (range 5-21). Preoperative knee functional score averaged 57 (range 23-95). The average range of movement was 116 degrees (range 100 degrees-140 degrees). Postoperatively, the average Melbourne knee score improved to 25 (range 11-30), while the knee function score was 85 (range 28 – 100). The difference was statistically significant (P<0.05). Eighty-five percent rated the result as good or excellent, while 12% rated it as fair. Five percent thought the result was poor. The most common complaint was clicking at 40 degrees of flexion (n=7). Six patients underwent arthroscopic lateral release, which improved the symptoms in four patients. Two knees were revised one due to progression of tibiofemoral arthritis and the other due to persistent clicking, yielding a survival rate of 95.

Finally, in vivo, in MiaPaCa-2-derived xenografts, olaparib did not radiosensitize, whereas AZD1775 produced moderate, yet significant, CCI-779 order radiosensitization (P smaller than 0.05). Importantly, the combination of AZD1775 and olaparib produced highly significant radiosensitization (P smaller than 0.0001) evidenced by a 13-day delay in tumor volume doubling (vs. radiation alone) and complete eradication of 20% of tumors. Conclusions: Taken together, these results demonstrate the efficacy of combined inhibition of Wee1 and PARP inhibitors for radiosensitizing pancreatic cancers

and support the model that Wee1 inhibition sensitizes cells to PARP inhibitor-mediated radiosensitization through inhibition of HRR and abrogation of the G(2) checkpoint, ultimately resulting in unrepaired, lethal DNA damage and radiosensitization. (C)2014 AACR.”
“Nitric

oxide (NO) is the principal mediator of penile erection, and soluble guanylate cyclase (sGC) is the receptor for NO. In pathophysiological conditions when sGC is inactivated and not responsive to NO or sGC SN-38 supplier stimulators a new class of agents called sGC activators increase the activity of NO-insensitive sGC and produce erection. The aim of this study was to investigate erectile responses to BAY 60-2770, a sGC activator, under physiological and pathophysiological conditions. In the present study increases in intracavernosal pressure (ICP) in response to intracavernosal (ic) injections of BAY 60-2770 were investigated under baseline conditions, when sGC was inhibited by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), when nitric oxide synthase (NOS) was inhibited by N-nitro-L-arginine methyl ester (L-NAME), and after cavernosal nerve crush injury. Under baseline conditions ic injections of BAY

60-2770 increase ICP, ICP/mean arterial pressure (MAP), and area under the ICP curve (AUC) and produce small decreases in MAP at the highest doses studied. BAY 60-2770 was very potent in its ability to induce erection and responses to BAY 60-2770 were enhanced by ODQ which attenuates erectile responses to sodium nitroprusside (SNP), diethylamine NONOate (DEA/NO), and cavernosal nerve stimulation. Responses to BAY 60-2770 were not altered by L-NAME or cavernosal nerve MK-0518 Microbiology inhibitor crush injury. These data indicate that BAY 60-2770 has potent erectile activity that is enhanced by ODQ and show that responses to BAY 60-2770 are not attenuated by NOS inhibition or cavernosal nerve injury. These results suggest that BAY 60-2770 would be effective in the treatment of erectile dysfunction when NO bioavailability is reduced, after pelvic nerve injury, and when sGC is oxidized.”
“Consanguinity promotes homozygosity of recessive susceptibility gene variants and can be used to investigate a recessive component in diseases whose inheritance is uncertain.

The depletion of endogenous

cIAP1/2 by their specific inhibitor MV1 or their siRNA-mediated knockdown resulted in enhanced RANKL-induced NFATc1 expression and osteoclastogenesis without affecting the activation of the NF-?B and buy LY2603618 MAPK pathways. In combination, these results indicate that cIAP1/2 negatively regulate osteoclastogenesis by inhibiting NFATc1 mRNA expression in a manner that is distinct from the previously identified functions of cIAP1/2.”
“Objective: The objective of this paper is to investigate demographic and disease factors associated with changes in employment role and status in multiple sclerosis (MS).\n\nMethods: Questionnaires on current symptoms, employment status and factors associated with

changes in employment were sent to a community sample of 566 MS patients.\n\nResults: A total of 221 completed questionnaires were analysed. Of 169 employed at diagnosis, 43.3% had left employment at a mean of 11.9 years after disease onset. Of those still employed, 55% had changed their role or working hours to accommodate symptoms relating to their disease. These patients reported greater fatigue (p = 0.001), pain (p = 0.033) and memory problems (p = 0.038) than those whose employment had remained selleck products unaffected. Multinomial logistic regression revealed the factors most strongly predictive of employment status were disability level, years of education, disease duration and fatigue (p = 0.032).\n\nConclusions: Despite changes to public perceptions

and legislative protection over the last 20 years, high rates of MS patients still leave the workforce prematurely, reduce working hours or change employment roles. These data have significant implications AZD8055 concentration when considering social and economic impacts of MS, support the value of employment metrics as long-term outcome measures, and demonstrate the need to improve employment requirements and flexibility of working practices in individuals with MS.”
“Objective: To determine the genetic etiology of the severe early infantile onset syndrome of malignant migrating partial seizures of infancy (MPSI).\n\nMethods: Fifteen unrelated children with MPSI were screened for mutations in genes associated with infantile epileptic encephalopathies: SCN1A, CDKL5, STXBP1, PCDH19, and POLG. Microarray studies were performed to identify copy number variations.\n\nResults: One patient had a de novo SCN1A missense mutation p.R862G that affects the voltage sensor segment of SCN1A. A second patient had a de novo 11.06 Mb deletion of chromosome 2q24.2q31.1 encompassing more than 40 genes that included SCN1A. Screening of CDKL5 913/15 patients), STXBP1 913/15), PCDH19 99/11 females), and the 3 common European mutations of POLG 911/15) was negative. Pathogenic copy number variations were not detected in 11/12 cases.

This is the first report of a rabies outbreak in the greater Johannesburg area with evidence of local transmission in the domestic dog population.”
“Urtica dioica or stinging nettle is traditionally used as an herbal medicine in Western Asia. The current study represents the investigation of antimicrobial activity of U dioica

from nine crude extracts that were prepared using different organic solvents, obtained from two extraction methods: the Soxhlet extractor (Method I), which included the use of four solvents with ethyl acetate and hexane, or the sequential partitions (Method II) with a five solvent system (butanol). The antibacterial and antifungal activities of crude extracts were tested against 28 bacteria, three yeast strains and seven fungal isolates by the disc diffusion and broth dilution methods. Amoxicillin was used as BLZ945 order positive control for bacteria strains, vancomycin for Streptococcus

sp., miconazole nitrate (30 mu g/mL) as positive control for fungi and yeast, and pure methanol NVP-LDE225 clinical trial (v/v) as negative control. The disc diffusion assay was used to determine the sensitivity of the samples, whilst the broth dilution method was used for the determination of the minimal inhibition concentration (MIC). The ethyl acetate and hexane extract from extraction method I (EA I and BE I) exhibited highest inhibition against some pathogenic bacteria such as Bacillus cereus, MRSA and Vibrio parahaemolyticus. A selection of extracts that showed some activity was further tested for the MIC and minimal bactericidal concentrations (MBC). MIC values of Bacillus subtilis and Methicillin-resistant Staphylococcus aureus (MRSA) using butanol extract of extraction method

II (BE II) were 8.33 and 16.33mg/mL, respectively; while the MIC value using ethyl acetate extract of extraction method II (EAE II) for Vibrio parahaemolyticus was 0.13mg/mL. Our study showed that 47.06% of extracts inhibited Gram-negative (8 out of 17), and 63.63% of extracts also inhibited Gram-positive bacteria (7 out of 11); besides, statistically the frequency of antimicrobial activity was 13.45% (35 out of 342) which in this among 21.71% belongs to antimicrobial activity extracts from extraction method I (33 out of 152 of crude extracts) and 6.82% from extraction selleck chemical method II (13 out of 190 of crude extracts). However, crude extracts from method I exhibited better antimicrobial activity against the Gram-positive bacteria than the Gram-negative bacteria. The positive results on medicinal plants screening for antibacterial activity constitutes primary information for further phytochemical and pharmacological studies. Therefore, the extracts could be suitable as antimicrobial agents in pharmaceutical and food industry. Rev. Biol. Trop. 60 (4): 1567-1576. Epub 2012 December 01.”
“Carpal tunnel syndrome is treated very successfully by surgical release of the flexor retinaculum.

“
“Aim: To estimate an equivalent to the Modified Mini-Mental State Exam (3MSE), and to compare changes in the 3MSE with and SNS-032 datasheet without the estimated scores. Methods: Comparability study on a subset of 405 participants, aged >= 70 years, from the Cardiovascular Health Study (CHS), a longitudinal study in 4 United States communities. The 3MSE, the Telephone Interview for Cognitive Status (TICS) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) were administered within 30 days of one another. Regression models were

developed to predict the 3MSE score from the TICS and/or IQCODE, and the predicted values were used to estimate missing 3MSE scores in longitudinal follow-up of 4,274 CHS participants. Results: The TICS explained 67% of the variability in 3MSE scores, with a correlation of 0.82 between predicted and observed scores. The IQCODE alone was not a good estimate of 3MSE score, but improved the model fit when added to the TICS model. Using estimated 3MSE scores classified more participants with low cognition, and rates of decline were greater than when only the observed 3MSE scores AZD9291 in vitro were considered. Conclusions: 3MSE scores can be reliably estimated from the TICS, with or without the IQCODE. Incorporating these estimates

captured more cognitive decline in older adults. Copyright (C) 2009 S. Karger AG, Basel”
“PurposeRecently developed neuronal check details current magnetic resonance imaging aims to directly detect neuronal currents associated with brain activity, but controversial results have been reported in different studies on human subjects. Although there is no dispute that local neuronal currents produce weak transient magnetic fields

that would attenuate local MR signal intensity, there is not yet consensus as to whether this attenuation is detectable with present magnetic resonance imaging techniques. This study investigates the magnitude of neuronal current-induced signal attenuation in human visual cortex.\n\nTheoryA temporally well-controlled visual stimulation paradigm with a known neuronal firing pattern in monkey visual cortex provides a means of detecting and testing the magnitude of the neuronal current-induced attenuation in neuronal current magnetic resonance imaging.\n\nMethodsPlacing a series of acquisition windows to fully cover the entire response duration enables a thorough detection of any detectable MR signal attenuation induced by the stimulus-evoked neuronal currents.\n\nResultsNo significant neuronal current-induced MR signal attenuation was observed in the putative V1 in any participated subjects.\n\nConclusionThe present magnetic resonance imaging technique is not sensitive enough to detect neuronal current-induced MR signal attenuation, and the upper limit of this attenuation was found to be less than 0.07% under the study condition. Magn Reson Med 71:756-762, 2014.

Our aim was to determine the association between elevated fibrinogen and decreased high-density lipoprotein cholesterol (HDL-C) levels with selleck kinase inhibitor recurrent CVT. Methods: This retrospective cohort study included participants if they had a first episode of objectively defined CVT and were admitted to Xuan Wu Hospital, Capital Medical University from August 2005 to September 2009. Demographic and clinical variables were collected, as well as laboratory parameters, including plasma fibrinogen and HDL-C. Patients with CVT were followed

for recurrent symptomatic CVT. Follow-up was through the end of September 2010. Potential predictors of recurrence were analyzed using Cox survival analysis. Results: At the end of the follow-up, 95 patients were eligible for the study. Twelve of 95 patients (12.6%) had

recurred CVT. The median time of recurrence was 7 months (range: 1-39 months). Eight of these 12 (66.7%) experienced recurrence within the first 12 months after their initial CVT. The recurrence rate of CVT was 2.76 per 100 patient-years. Multivariate Cox regression analysis demonstrated that the coexistence of high fibrinogen ( bigger than 4.00 g/L) and low HDL-C ( smaller than 1.08 mmol/L) levels at baseline was the only independent predictor for recurrent CVT (hazard ratio: 4.69; 95% confidence interval: 1.10-20.11; P smaller than 0.05). Of the twelve patients with recurrent CVT in our study, 7 (58.3%) had high fibrinogen plus low HDL-C levels. All 7 of these patients took β-Nicotinamide mouse warfarin for 3-12 months, and 6 of 7 had recurrent CVT after the discontinuation of anticoagulant GSK690693 datasheet treatment. Conclusions: Concomitant high fibrinogen and low HDL-C levels may be associated with recurrence of CVT. The effect of potential risk factors related to atherothrombosis on recurrent CVT should be closely monitored.”
“Objectives There have been few reports regarding olanzapine (OLZ)-related QT prolongation and hyperprolactinemia. This study evaluated the

dose-dependent effect of OLZ on QT interval and plasma prolactin (PRL) level in a single sample of patients with schizophrenia.\n\nMethods Twenty-six subjects treated with varying starting doses of OLZ were enrolled in the study. Following baseline assessments, which included completion of the Brief Psychiatric Rating Scale (BPRS), measurements of Body Mass Index (BMI), QT interval, electrolytes, fasting plasma glucose, PRL, hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL), the dose of OLZ was increased for each subject. The same parameters were evaluated following the increased dose treatment.\n\nResults A significant decrease was observed in BPRS score (p=0.01) following treatment with an increased dose of OLZ. Significant increases were observed in BMI (p=0.032), QTc (p=0.031), and plasma PRL level (p=0.028).

In The Netherlands, systematic surveillance of gastroenteritis outbreaks of suspected viral etiology was established by the National Institute for Public Health and the Environment in 1994. Since 2002, the total number of outbreaks reported has been increasing, and with that comes the need

for sensitive assays that can be performed quickly. In addition, the diagnostic demand changed so that now the proportion of samples from hospitals is higher and there is a need for patient-based test results. In order to target the diagnosis of acute gastroenteritis, we reviewed our data on outbreaks of gastroenteritis and the prevalence of individual viruses to provide a priority list of viruses for which samples should be evaluated. Random primers were used to replace the separate specific primers selleck compound for each virus used in the reverse transcription steps. The individual PCR assays AZD2171 supplier were replaced by multiplex PCR assays. We employed a two-step method in which in the first step we screened for the most common causes of viral gastroenteritis, noroviruses of genogroup II and rotaviruses of group A, with equine arteritis virus used as the internal control. Subsequently, in the second step, two parallel PCR assays were developed for the detection of noroviruses of genogroup I and equine arteritis virus in one run and adenoviruses, sapoviruses, and astroviruses in the other run. The specificities

of the assays were calculated to be 92.5% for the assay for noroviruses of genogroup I and 100% for the assays for all other viruses, the detection limits were equal for all viruses, and the turnaround time was reduced to 1 day compared to the at least 3 days required for the methods used previously. This approach allows the targeted, rapid, and cost-effective elucidation of the causes of acute gastroenteritis outbreaks.”
“Voltage-gated

potassium channel antibody (VGKC-Ab)associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum this website of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures.”
“Scope: The aim of the present study was to examine the neuroprotective effect of curcumin against the toxicity induced by acrolein and to identify its cellular mechanisms and targets.\n\nMethods and resultsHuman neuroblastoma cells SK-N-SH were treated with acrolein.