054 to 0.105, p < 05) In analyses adjusting for baseline cognitive scores, asymptomatic atherosclerotic

disease, and cardiovascular risk factors, both markers predicted decline in several cognitive domains (excluding memory) Baseline plasma viscosity, but not hematocrit, was associated negatively with follow-up test scores for general AICAR cognitive ability, information processing speed, and mental flexibility (correlations = -0.050 to -0.098 p < 05) and with decline across the same domains (p < 05). Conclusions: Increased circulating levels of CRP, fibrinogen, and elevated plasma viscosity predicted poorer subsequent cognitive ability

and were associated with age-related cognitive decline in several domains. including general ability.”
“Several empirical lines of investigation support the idea that syllable-sized units may be involved in visual word recognition processes. In this perspective, the present study aimed at investigating further the nature of the process that causes syllabic effects in reading. To do so, the syllable frequency effect was investigated in French selleck chemicals using event related potentials while participants performed a lexical decision task (Experiment 1). Consistent with previous studies, manipulating the frequency of the first syllable in words and pseudowords yielded two temporally distinct effects. Compared to items with a Eltrombopag first syllable of low frequency, items with a syllable of high frequency elicited a weaker P200 component, reflecting early sub-lexical facilitation, and a larger N400

component, supposed to ensue from competition between syllabic neighbours. To examine which factors determine the strength of interference during lexical access, regression analyses were conducted on the late temporal window potentials. The inhibitory syllable frequency effect was best predicted by leader strength, that is, the frequency ratio between the most frequent syllabic neighbour and the others. When this variable was directly manipulated while controlling for syllable frequency and number of higher frequency syllabic neighbours (Experiment 2), electrophysiological data confirmed the impact of leader strength.