1038/leu.2009.194; published online 1 October 2009″
“This study was undertaken to investigate the neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) on 6-hydroxydopamine (6-OHDA)-induced rats with Parkinson’s disease. rTMS
was given to rats with Parkinson’s disease induced by 6-OHDA, daily for 4 weeks to examine the protective effects. Rotational test showed that rTMS significantly attenuated apomorphine-induced turns in rats with Parkinson’s disease. Tissue processing showed that rTMS alleviated 6-OHDA-induced loss of dopaminergic neurons in rat substantia nigra. Furthermore, rTMS decreased the levels of cyclooxygenase-2 NU7441 order and tumor necrosis factor-a in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with Parkinson’s disease. NeuroReport 21:268-272 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“The objective of this study for newly diagnosed acute promyelocytic Leukemia (APL) was to evaluate the efficacy of an intensified double induction chemotherapy including high dose ara-C (HD) and all-trans retinoic acid (ATRA) followed by consolidation and 3 years maintenance therapy. In contrast to APL studies stratifying therapy according to pretreatment white blood cell (WBC) count < and >= 10 x 10(9)/l (low/intermediate and high
risk according to the Sanz score), our patients received uniform therapy. From 1994 to 2005, 142 patients (age, 16-60 SHP099 concentration years) were enrolled. In the low/intermediate (n = 105) vs high (n = 37) WBC group, the rates of complete remission were 95.2 vs 83.8%, of induction death were 4.8 vs VE-822 ic50 16.2% (P = 0.05) and of molecular remission were 87.5 vs 91.3% (P = 1). Long-term overall survival was 84.4 vs 73.0% (P = 0.12), event free survival was 78.3 vs 67.3% (P = 0.11), relapse free survival was 82.1 vs 80.0% (P = 0.83) and the cumulative incidence of relapse was 7.4 vs 11.4% (P = 0.46). No relapse or death occurred after 4.7 years. ATRA and intensified chemotherapy including
HD ara-C followed by prolonged maintenance therapy reduced the relapse risk in high risk patients. Pretreatment WBC count >= 10 x 10(9)/l count was no relevant prognostic factor for relapse. Leukemia (2009) 23, 2248-2258; doi:10.1038/leu.2009.183; published online 10 September 2009″
“Despite a well-established relationship between amygdala activation during learning and long-term memory, contributions of amygdala to immediate memory have not been studied to date. We used functional magnetic resonance imaging at 1.5-T field strength to determine whether amygdala responses to emotional pictures would predict performance on an immediate recognition memory test. Sex differences in amygdala activation were related to false-positive error rates in recognizing unpleasant pictures.