3% in group B respectively) and infection period (26.3±11.6h in group A and 24.9±13.8h in group B respectively) in group

B. Meanwhile, in group B, the wound healing time was shorter than group A statistically in both taintless cases (9.12±1.30d in group A and 6.57±0.49d in group B respectively) and infected cases (14.24±2.63d in group A and 10.65±1.69d in group B respectively). Conclusion The facial laceration of dog bite wounds should be primary closed immediately after formal and thoroughly debridement. And the primary closure would shorten the healing time of the dog bite wounds without increasing the rate and period of infection. There is no potentiality of increasing infection Inhibitors,research,lifescience,medical incidence and infection speed, compared immediate primary closure with the wounds left open. On the contrary, primary closure the wounds can promote its primary healing. Prophylactic antibiotics administration was not recommended. Inhibitors,research,lifescience,medical and the important facial organ or tissue injuries should be secondary reconditioned. Background In recent years, more and more people suffered from dog bite, along with the increasing amount of domesticated dogs.

According to the data from the Centers for Disease Control and Prevention (CDC) of Beijing, there was Inhibitors,research,lifescience,medical over 100,000 people were attacked by dogs in 2007 in Beijing, which exceeded over 180,000 in 2011. About 10% of dog bite cases were facial wounds. As a special Inhibitors,research,lifescience,medical type of wound, dog bite wound had its characters, such as high infection rate and serious complications. The local infection, sometimes even intracranial infection, of the facial dog bite wound was inevitable and unmanageable generally. Although some pertinent literature have been published about dog bite facial wound, prospective studies was rarely concerned. At present, controversial focus existed about facial dog bite laceration management: One is whether it’s appropriate to perform immediate primary closure; another Inhibitors,research,lifescience,medical is whether it is essential to give prophylactic antibiotic. In order to get a definite answer about these topics, we carried out this prospective trial study. Patients and methods Patients of all ages and gender

attending Rabies Prophylaxis and Immunity Clinic of Beijing with facial Brefeldin_A dog bite were enrolled in the prospective, randomized trial. The facial lacerated wounds requiring surgical treatment (more than 2cm) were entered into the trial. Punture wounds (less than 2mm), small laceration (less than 2cm), infected wounds at presentation or visited doctor’s office after injured more than 8h, wounds with skin loss requiring plastic surgery, or patients with immune deficiency, using immunosuppressive agent, autoimmune disorder and diabetes were excluded. All the patients were randomized by block randomization and distributed to control group A and trail group B by block random digits table. The Crenolanib manufacturer therapeutic schedules were explained to the patients in each group, and the consent form was signed.