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“Introduction The global health effort to eradicate poliomyelitis (polio) has encountered a number of unforeseen and unpredictable challenges which have been well documented [1]. This article provides a timely review of these challenges and looks toward overcoming the remaining barriers to eradication. Methods The authors undertook a comprehensive literature review using the Internet and the databases JSTOR, PubMed, ScienceDirect and SwetsWise.