The research articles both in English and Chinese involving Realgar had been recovered from five databases including CNKI, Wanfang, VIP, SinoMed, and Web of Science. And NoteExpress, a literature administration computer software was utilized to monitor literature. CiteSpace had been utilized for visualized evaluation and presentations of the authors, institutions, and keywords. 2 879 articles in Chinese and 194 articles in English had been included. China Journal of Chinese Materia Medica and Journal of Ethnopharmacology had been the utmost effective Chinese and English journals when it comes to publication amount. Realgar is widely used when you look at the treatment of epidermis diseases, blood conditions, and disease. JIANG Hong had been the author who have published much more articles in Chinese and English using the services of groups. School of Public wellness of Asia health University and China Academy of Chinese Medical Sciences published the essential articles in Chinese and English. The research on Realgar mainly centers on medical application, mechanism of action, reduced total of poisoning, and enhancement of efficacy. The authors and establishments of Realgar research are primarily focused in China. The analysis in the system of treating hematological diseases and cancer with Realgar, as well as the research on its ramifications of reducing toxicity and boosting effectiveness, would be the current research hotspots. The system of "same treatment for various diseases" in Realgar should be further explored. It really is urgent to carry out interdisciplinary research on Realgar. This research can provide a refe-rence for the clinical application of Realgar and provide ideas for additional research on Realgar.Based on the R language data mining technology, the medication rules of old-fashioned Chinese medicine(TCM) within the remedy for H-type high blood pressure had been discussed, while the basis and brand new some ideas to treat H-type hypertension with TCM were offered. CNKI, Wanfang, VIP, and SinoMed were searched to gather clinical studies on the remedy for H-type high blood pressure with TCM. The information had been screened, and Excel was made use of to build a database. Rstudio was used to undertake medicine effectiveness classification, four Qi and five flavors, meridian homing, regularity of good use, correlation, organization rules, and clustering analyses of drugs and explore the medicine rules of TCM. 191 TCM prescriptions were acquired, in addition to main syndromes were phlegm-dampness buildup syndrome, phlegm and blood stasis problem, and Yin deficiency and Yang hyperactivity syndrome. A complete of 169 types of TCM were used, plus the frequency ended up being 1 875 times. Included in this, the medicines whose solitary use regularity was a lot more than 20 times were high-frequencscriptions had been obtained by cluster evaluation. The pathological factors of H-type hypertension tend to be mainly phlegm, stasis, and deficiency. The illness site is in the liver, concerning the spleen, lung area, along with other viscera. The popular drugs are Gestrodiae Rhizoma, Poria, Pinelliae Rhizoma, Achyranthis Bidenthis Radix, etc. Banxia Baizhu Tianma Decoction, Tianma Gouteng Decoction, and Buyang Huanwu Decoction can be used prescriptions. The medication rules shown in this study provides certain some ideas for the clinical treatment of H-type hypertension with TCM.In order to analyze the similarities and distinctions of substance compositions between your origins and stems and leaves of Isodon japonicus(IJ), this study applied UPLC-Q-TOF-MS technology to methodically characterize its chemical compositions, analyzed and identified the construction of the primary compounds, and established a technique for multiple determination of the content by refe-rence material. A complete of 34 major substances in IJ, including 14 reference compounds, were identified or predicted on line. More over, an UPLC-UV content determination strategy was developed for 11 substances [danshensu, caffeic acid, vicenin-2,(1S,2S)-globoidnan B, rutin,(+)-rabdosiin,(-)-rabdosiin,(1S,2S)-rabdosiin, shimobashiric acid C, rosmarinic acid, and pedalitin]. The strategy exhibited exceptional Genetic hybridization separation, security, and repeatability, with an extensive linear range(0.10-520.00 μg·mL~(-1)) and large linearity(R~2>0.999). The typical data recovery rates ranged from 94.72% to 104.2per cent. The principal element analysis(PCA) demonstrated a definite difference between the roots and stems and leaves of IJ, indicating great split by group. Additionally, the orthogonal limited minimum squares discriminant analysis(OPLS-DA) model was Brain infection used, and six main differentially identified substances had been identified rosmarinic acid, shimobashiric acid C, epinodosin, pedalitin, rutin, and(1S,2S)-rabdosiin. In summary, this study established a technique and way of differentiating some other part of IJ, providing a very important tool for quality-control of IJ and a basis for the ratio-nal application and sustainable development of IJ.In order to characterize and recognize the chemical components in numerous components of Artemisia argyi(roots, stems, leaves, and seeds), compounds with antioxidant task had been screened. In this research, ultra-performance liquid chromatography-2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt-quadrupole time-of-flight-tandem mass spectrometry(UPLC-ABTS-Q-TOF-MS) had been used as an online combo method. Poroshell 120 SB-Aq(3.0 mm×150 mm, 2.7 μm) was used as the column, and acetonitrile(A)-0.2% formic acid water(B) ended up being followed OTSSP167 supplier since the cellular period to do gradient elution and had been scanned in negative and positive ion modes.