, Feb 2002). Subsequently, socioeconomic status was also observed to be positively associated with striatal D2 receptor binding availability in men and women (Martinez et al., Feb 1 2010). Striatal D2

receptor binding availability was also positively associated with perceived social support in this study, emphasizing the importance of positive social relationships (Martinez et al., Feb 1 2010). Coronary heart disease is caused by coronary artery atherosclerosis (CAA) and its sequelae. Cynomolgus monkeys have been useful models to study factors that affect the development of CAA. Among female cynomolgus macaques, subordinates have about twice as extensive CAA as dominants, a difference which has been observed in multiple studies (Kaplan Linsitinib purchase et al., Sep 2009). Both poor ovarian function and exaggerated heart rate responses to acute stress are associated with increased CAA extent. These characteristics of subordinates may provide mechanistic paths to increased atherogenesis. About 25 years ago, we began observing and recording the frequency and percent time spent in a behavior termed “depressive”, in which the monkeys sat in a slumped or collapsed body posture with open eyes, accompanied by a lack of responsivity to environmental events (Fig. 1D).

This behavior was reminiscent of that described in infant macaques removed from their Talazoparib clinical trial mothers and adults following separation from their family environment (Suomi et al., 1975). We have observed this depressive behavior in three separate groups of female monkeys (a total of 120 animals). Interobserver agreement in the identification of depressive behavior was greater than 92% in all experiments. Rates of depression were similar in the three experiments (38–45%) (Shively et al., Apr 15 1997, Shively et al., Apr 2005 and Shively et al., 2014). Depressive behavior was more common in subordinate females; 61% of

subordinates displayed depressive behavior while only 10% of dominants exhibited this behavior (Shively et al., Apr 15 1997). Social subordination and depression are not homologous; subordinate and depressed monkeys differ GPX6 in neurobiological and behavioral characteristics (Shively and Willard, Jan 2012) and 39% of subordinates did not display depressive behavior and a few dominants did, suggesting individual differences in stress sensitivity and resilience (Shively et al., Apr 15 1997). We concluded that the stress associated with low social status may increase the likelihood of depressive behavior. Rates of depression in the human population are also inversely related to socioeconomic status (AdlerRehkoph, 2008 and Lorant et al., Jan 15 2003). The fact that many, but not all, socially subordinate females and only a few dominant females exhibit depressive behavior indicates unexplained variability that may be due to variation in the social environment, or to individual differences in sensitivity or resilience to social stress (Bethea et al., Dec 2008).