For example, liver uptake [Cu-64]ch14.18-p-NH2-Bn-NOTA was 4.74 +/- 0.77 per cent of the injected dose per gram of tissue (%ID/g), and for [Cu-64]ch14.18-SarAr was 8.06 0.77 %ID/g. Differences in tumor targeting https://www.selleckchem.com/products/BI6727-Volasertib.html correlated with variations in tumor size rather than which BEG was used.
Conclusions: The results of this study indicate that differences in the thermodynamic stability of these chelator-Cu(II) complexes were not associated with significant differences in uptake of the tracer by the tumor.
However, there were significant differences in tracer concentration in other tissues, including those involved in clearance of the radioimmunoconjugate (e.g., liver and spleen). (C) 2011 Elsevier Inc. All rights reserved.”
“Objectives: The Fontan-type procedure has undergone 2 major modifications, including intra-atrial baffling and extracardiac conduit. To clarify the effect of these modifications on arrhythmia propensity, we analyzed chronologic changes in P-wave characteristics after atriopulmonary connection, intra-atrial baffling, or extracardiac conduit.
Methods: A retrospective analysis was
conducted on electrocardiographic data from 40 patients with tricuspid atresia who underwent the Fontan-type procedure and follow- up for greater than 5 years: 18 had atriopulmonary connection, 13 had intra-atrial baffling, and 9 had EX 527 price extracardiac conduit. The mean follow- up period in years was 19.8 for atriopulmonary connection, 13.3 for intra-atrial baffling, and 8.0 for extracardiac conduit. We analyzed chronologic changes in P-wave duration, dispersion, and amplitude and prevalence of Selleck CHIR 99021 sinus node dysfunction.
Results: Atrial tachyarrhythmia
was documented in 9 patients with atriopulmonary connection but not in any patients with extracardiac conduit or intra-atrial baffling. Both P-wave maximum duration and dispersion decreased slightly over time with extracardiac conduit but increased progressively in the intra-atrial baffling and atriopulmonary connection groups. Intra-atrial baffling resulted in significantly shorter P-wave duration than atriopulmonary connection, whereas extracardiac conduit had significantly shorter P-wave duration and smaller dispersion than atriopulmonary connection and intra-atrial baffling. P-wave amplitude decreased markedly immediately after surgical intervention with intra-atrial baffling and extracardiac conduit but remained unchanged in patients undergoing atriopulmonary connection. Sinus node dysfunction was found commonly in all 3 groups.
Conclusion: After intra-atrial baffling, patients increasingly had prolonged P-wave duration and larger dispersion associated with sinus node dysfunction, suggesting a propensity to arrhythmia, although less progressive than seen in those undergoing atriopulmonary connection.