Seventy years old girl noticed a mass in her correct breast before 36 months. Since she had ulcer bleeding, she went to our medical center. In physical findings, a hemorrhagic about 8 cm mass with an ulcer ended up being found in the top right breast. Breast ultrasonography revealed a sizable cyst of approximately 8 cm within the right A area, and needle biopsy disclosed invasive ductal carcinoma(ER positive, PgR good, HER2 good, Ki-67 low appearance). Right axillary lymph node metastasis had been verified, but no clear distant metastasis was observed. Pretreatment diagnosis was correct breast disease, cT4bN1M0, Stage ⅢB, Luminal HER. Chemotherapy was started with pertuzumab, trastuzumab, and docetaxel, therefore the tumefaction had been paid off after 6 cycles. Due to-side effects, the medication was altered to a molecular targeted medicine just and also the therapy had been continued. Nonetheless, redness had been observed in the entire right breast, and breast cancer skin metastasis was Protein Tyrosine Kinase inhibitor suspected. Considering that the dermatitis due to metronidazole serum was also distinguished, the redness had been improved if the application had been ended. Whenever confirmed by a patch test, a reaction to metronidazole serum ended up being observed, ultimately causing the diagnosis of dermatitis caused by metronidazole gel.A 21-year-old girl was accepted for preshock as a result of serious anemia. A 5 cm gastrointestinal stromal tumor(GIST)at the jejunal flexure of her duodenum was identified by enhanced CT evaluation. We performed an overall total laparoscopic pancreas- preserving duodenal sleeve resection with a 2 cm margin from the tumefaction. Useful end-to-end anastomosis was through with the patient lying in a right half lateral decubitus place so that you can shift the extra weight regarding the Recurrent infection tumor and duodenal mesentery off to the right to avoid medical capsule damage. We experienced one case(5.5%)of peritoneal(recurrent)GIST after laparoscopic gastrectomy. However, this is usually a safe and helpful means of laparoscopic duodenal sleeve resection of duodenal GIST at a distal part through the papilla Vater, whenever performed by a skilled team.A 73-year-old man served with anemia, and gastroscopy revealed a nonpigmented tumor into the esophagogastric junction. Caused by the tumor biopsy initially suspected poorly classified adenocarcinoma. Nevertheless, extra immunohistochemical evaluation disclosed malignant melanoma. The ultimate diagnosis was amelanotic cancerous melanoma for the esophagogastric junction with adrenal and spinal metastasis. Although immunotherapy was done, the in-patient died 132 times after diagnosis.We report a rare instance of cavitary lung metastasis of rectal disease, identified initially as septic pulmonary embolism. A 55- year old girl underwent crisis Hartmann’s procedure for perforation associated with rectal cancer with multiple liver metastases. A 2 cm-sized thin-walled cavitary lesion ended up being noticed in the remaining upperlobe associated with lung by CT, and septic pulmonary embolism was suspected. She recoverd from sepsis after intensive care treatment. Pathological analysis is adenocarcinoma (tub2), T3N1M1, Stage Ⅳ, she underwent chemotherapy. Serum CEA level was high preoperatively but gradually reduced to normal 4 months following the operation. Multiple liver metastases revealed calcification, additionally the lung lesions remained unchanged on CT. She continued chemotherapy while switching the anticancer medicine as a result of complications. One-year and 5 months after operation, lung CT showed thickened wall surface and spicula round the cavitary lesion. Serum CEA level ended up being typical biocide susceptibility , SLX and NSE somewhat increased and serum aspergillus antigen was positive. Bronchial lavage cytology was Class Ⅰ and scrape cytology had been Class Ⅲ in bronchoscopy. Lung metastasis, primary lung cancer or aspergilloma had been suspected and then we performed limited lung resection. The pathological diagnosis ended up being rectal cancer lung metastasis.The patient, a male in the 70s, visited our hospital with a chief complaint of basic fatigue and weightloss. Upon a detailed evaluation, he was identified as having sigmoid colon cancer, para-aortic lymph node metastases, and multiple liver metastases, which is why he had been hospitalized due to an unhealthy performance status(PS). FOLFOX therapy ended up being administered while the symptoms due to the principal lesion weren’t acknowledged and his general condition was regarded as poor and therefore he was considered become inoperable. After finishing 2 classes for the chemotherapy, although his PS improved, laparoscopic sigmoidectomy had been performed with colonic stent positioning due to your incident of an intestinal obstruction because of an enlargement of this main lesion. Following surgery, 2 courses of FOLFOX therapy and 4 classes of FOLFOX plus bevacizumab therapy had been administered in which he is live at 5 months following the operation without progression.A 56-year-old man offered to our hospital with melena, and had been identified as having locally advanced sigmoid colon cancer invading the trigone for the bladder(cT4bN0M0). mFOLFOX6 plus panitumumab had been administered as a preoperative chemotherapy. After 6 programs of administration, the key cyst shrunk but the bladder intrusion remained. We told the individual that resection of the bladder was required for radical remedy for the cyst. As he refused a urostomy for urinary reconstruction, we opted ileal neobladder reconstruction and performed reduced anterior resection plus total cystectomy, which resulted in pathologically curative resection. No recurrence and very little bladder control problems took place throughout the 8 months following the operation.