However, all eligible children with CKD from the Nephrology Pediatric Center of IMIP were selleckchem included. It is noteworthy, however, that this study is the in Brazil to evaluate QoL through PedsQLTM in children and adolescents with CKD. Finally, it is concluded
that the study sample showed a significant reduction in QoL, functional capacity, and physical activity in children and adolescents with CKD. Positive associations were also found between functional capacity, pulmonary function, and QoL. However, no correlation was found between respiratory muscle strength and functional capacity, suggesting the need for new studies to better elucidate this finding. The authors declare no conflicts of interest. “
“Neoplasms have become important in the epidemiological scenario, as they represent one of the leading causes of death of in the 1 to 19 years age group in Brazil, second only to external causes, in 2010, despite the rarity of
childhood cancer when compared to adults.1 In children, tumors are usually categorized into 12 specialty groups, according to the Third Edition of the International Classification of Childhood Cancer (ICCC). Leukemias constitute Group I, which comprises the subgroups: acute lymphocytic leukemia; acute myeloid leukemia; and chronic myeloproliferative disorders, including chronic myeloid leukemia and unspecific or combined types. Chronic lymphocytic leukemia is extremely rare in children and was therefore included in the subgroup selleck kinase inhibitor of acute lymphocytic leukemia, the predominant type of leukemia in children, without affecting the incidence rates in this subgroup.2 Acute lymphoblastic leukemia represents the majority of cases among the diagnostic groups of lymphocytic leukemias (99%), so that the diagnosis
group of ICCC becomes synonymous with acute lymphocytic leukemia. Likewise, acute nonlymphocytic leukemias are referred to as acute myeloid leukemia (representing 69%) and chronic myeloid leukemia, with 6-7% representation in its group.3 Leukemias have the highest incidence rates among childhood tumors in Brazil and worldwide. In a study conducted Methane monooxygenase in the United States, of all neoplasms, leukemias showed a frequency of 26.3%. In Brazil, they were also the most prevalent in 20 population-based cancer registries, with a median percentage of 29%, with the highest incidence occurring in the age group 1-4 years, with a median percentage of 31.6%. Leukemia was the leading cause of death among cancers in children and adolescents (1-18 years) from 2001 to 2005 in Brazil, with 1,897 deaths in females and 2,539 deaths in males.4 The present study aimed to assess the trend of mortality from childhood leukemia in Brazil from 1980 to 2010. This is an ecological, retrospective, time-series study based on secondary data.