Reduced spectral power in posterior regions correlated with

decreased area of the posterior segments of the corpus callosum. Atypical cortical oscillatory activity is associated with reduced transcallosal connectivity in children with spina bifida. NeuroReport 20:1188-1192 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate buy GSK2118436 receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing receptors. Here, we report that GLYX-13 potently reduces delayed (24 Selleckchem MK-0518 h) death of CA1 pyramidal neurons produced by bilateral carotid occlusion in Mongolian

gerbils, when administered up to 5 h post-ischemia. GLYX-13 also reduced delayed (24 h) neuronal death of CA1, CA3, and dentate gyrus principal neurons elicited by oxygen/glucose deprivation in in-vitro hippocampal organotypic slice cultures, when applied up to 2 h post-oxygen/glucose deprivation. The glycine site full agonist D-serine completely occluded neuroprotection, indicating that GLYX-13 acts by modulating activation of this site. NeuroReport 20:1193-1197 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“Spectrotemporal receptive fields of nonlinear neurons in primary auditory cortex are stimulus dependent or context dependent. Here we show that a variant of stimulus-specific adaptation also contributes to this context dependence. Responses to sound stimulus frequencies close to the neuron’s best frequency adapt with an average time constant of approximately 7 s. In contrast, responses away from the best frequency do not adapt, but in fact slightly increase Rebamipide over our 30-s observation window. Such stimulus-specific

adaptation could function in enhancing stimulus discrimination and in maximizing neural information transmission by reducing redundancy. It also needs to be taken into account when comparing spectrotemporal receptive fields measured under adapted and nonadapted conditions. NeuroReport 20:1198-1203 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“During the past 12 years, lentiviral vectors have emerged as valuable tools for transgene delivery because of their ability to transduce nondividing cells and their capacity to sustain long-term transgene expression. Despite significant progress, the production of high-titer high-quality lentiviral vectors is cumbersome and costly. The most commonly used method to produce lentiviral vectors involves transient transfection using calcium phosphate (CaP)-mediated precipitation of plasmid DNAs. However, inconsistencies in pH can cause significant batch-to-batch variations in lentiviral vector titers, making this method unreliable.