Solomon. Exchanges of concepts subsequently occurred; in 1973, Solomon came to Poitiers to gather information on

the procedures we were employing at that time. A general consensus underlined the inexorable characteristic of the disease. Knowledge of the condition of the wheelchair-confined patients was minimal. That is why I spent long periods in Montreal for one decade, where I had the possibility to regularly definitely supervise one hundred patients who never benefited from even the slightest palliative management. They were allowed to live in accordance with their wishes and consequently they incarnated the natural course of the disease. This activity led to my residing in Montreal from 1977 to 1979, at the University Inhibitors,research,lifescience,medical Rehabilitation Institute. During this fruitful period, I studied the management practices, implemented in the main

institutions, that respected the principles put forward by G.E. Spencer and P.J. Vignos (e.g. m. tibialis Inhibitors,research,lifescience,medical posterior transfer, by D.A. Gibson in Toronto and J.D. Hsu in Los Angeles, taught to me by my dear fellow Louis Roy Inhibitors,research,lifescience,medical in Quebec; exceptional recourse to scoliosis surgery, also in Toronto and Los Angeles). My stay in Montreal was much more important for me, because, in collaboration with Raymond Lafontaine, a well-experimented pediatrician, we created in 1978 the first local myopathic clinic, at the Saint Justine Hospital. His vision on the handicaps was a revelation for me, and I wish to quote him: “Of course, correction of a physical impairment is important, but it does not avoid Inhibitors,research,lifescience,medical the disappointment of a child who sees his strength continue

to diminish. What matters most is to teach him how to accept his disability. The true way of reaching this goal Inhibitors,research,lifescience,medical consists in enabling him to develop all his intellectual faculties in such a way as to lead his life on his own”. In order to respect his advice, it was first of all necessary to than refute the non-reversing fatal prognosis of DMD patients, which was far from being the case at that time. For the recognized authorities on neuromuscular diseases, many of whom were English, the promise of survival was unthinkable: “Tracheostomy or long-term ventilation, even on an intermittent nocturnal basis, are rarely justifiable” (John Walton, in Disorders of Voluntary Muscle, University of Newcastle, UK, 1981). “Perhaps I might end by saying that I feel Dacomitinib strongly that tracheostomy should be avoided in patients with muscular dystrophy. It prevents the patient from being allowed to die in peace when the disease progresses to bulbar failure, which should remain as the final point” (personal letter from a specialist of a Respiratory Unit, Saint Thomas Hospital, London, November 1983). “Intermittent positive pressure ventilation with a nasal mask is an important recent advance which may have useful application to Duchenne Muscular Dystrophy […