Some of the specific functions of NO are as follows. Maintenance of Vascular Tone and Blood Pressure: Vascular tone is usually maintained by a steady release

of tiny amounts of NO from the vascular endothelium. This NO release is EPZ-5676 Histone Methyltransferase triggered by friction exerted by circulating cells (shear stress) and results in slight vasodilatation [13, 24]. Blood pressure and pulsate flow also regulate the release of NO under physiological conditions, with NO inhibition leading to a drastic increase in blood pressure [12, Inhibitors,research,lifescience,medical 25]. Regulation of Immunity and Inflammation: NO is an important cytotoxic mediator of activated immune cells capable of killing pathogenic agents, such as bacteria, parasites, and viruses, as well as tumor cells. NO can also inhibit the inflammation Inhibitors,research,lifescience,medical of blood vessels by blocking exocytosis of various mediators from endothelial cells, macrophages, and cytotoxic T lymphocytes [12, 13]. Inhibition of Monocyte and Neutrophil FTY720 S1P Receptor antagonist Adhesion to the Vascular Endothelium: NO donors have shown to be potent inhibitors of neutrophil

and monocyte adhesion to the vascular Inhibitors,research,lifescience,medical endothelium, a complicating factor in the pathogenesis of atherosclerosis [12, 26]. Antiproliferative Effects: Cellular proliferation in the muscular layer of the blood vessel has a Inhibitors,research,lifescience,medical key role in narrowing the vascular lumen. NO produced by the vascular endothelium or arising from exogenous donors can inhibit this proliferation although the mechanism underlying its antiproliferative activity is not well understood [12, 27, 28]. Antioxidative Effects: Oxidative stress contributes to thromboembolic disease. NO induces the production of the enzyme superoxide dismutase in the muscular layer of the blood vessels and in the extracellular Inhibitors,research,lifescience,medical space, decreasing the O2– available and the production of ONOO– [12, 29]. Regulation of Neurotransmission: NO regulates the activity of certain motor neurons in the parasympathetic branch of the autonomic nervous system [13]. Regulation

of Platelet Function: NO mediates the AV-951 adhesion and aggregation of platelets [13]. Direct and Indirect Stimulation of Endocrine and Exocrine Secretion: NO regulates the release of gonadotropin-releasing hormone (GSH) from the hypothalamus and adrenaline from the adrenal medulla as well as exocrine secretions (e.g., amylase from the pancreas) [13]. Regulation of Kidney Function: Release of NO at the level of the glomerulus increases blood flow and the rate of filtration, and urine formation [13]. Regulation of Reproductive Function: NO can improve penile erection, fertilization and uterine relaxation during pregnancy [13]. Role As a Messenger/Modulator: NO functions in a variety of essential biological processes [12].