The patient groups for which

our intervention is most suitable should be evaluated separately, considering that patients will receive therapy based on CBT and that the intervention focuses primarily on enhancing self-management. Our experience is restricted to patients suffering from IBS, CWP and T2DM and show that the providers who deliver the intervention should have a health care background and be trained in the intervention methodology, including the theory behind the intervention. Support from a GP or other physician who can be contacted in case of persisting psychological or chronic somatic health problems is important. In addition, the support from a multidisciplinary Alpelisib team is also considered to be advantageous. Several advantages of using the Internet to deliver self-care and behavior

change interventions are well recognized. Web-based interventions with a strong theoretical foundation can achieve positive results and may be successfully implemented in daily health care practice buy Gemcitabine [33]. Such interventions have the potential to substitute and/or support treatments in daily practice, making it possible to deliver tailored and personalized interventions with a large scalability that may have low marginal costs per additional user. Several studies suggest that web-based interventions have the potential to be highly cost-effective [41] and [42]. To achieve a successful implementation in daily practice of the developed intervention a conceptual framework and implementation protocol is strongly Fossariinae recommended. Kilbourne et al. [43] described a framework called Replicating Effective Programs (REP) and concluded that REP is a well-suited framework for implementing health care interventions.

The main components of REP are intervention, packaging, training, technical assistance and fidelity assessment. As we mentioned before, training of health care providers in CBT-based treatment is important for the implementation of our proposed intervention. Training is also one of the main components of REP and covers a large dimension in the implementation process [43]. In the USA the government, represented by Centers for Disease Control and Prevention (CDC) and health departments, funds the implementation of REP-packaged interventions by over 500 prevention organizations nationwide [44] and in Norway the Norwegian Government represented by the Norwegian Research Council and other minor actors also funds such implementation projects [45]. Positive impact in health outcomes associated with economic gain is highly prioritized. Sustaining changes achieved in the implementation process may require strategies beyond financial incentives, such as the dissemination of results on improved outcomes [43]. Further studies are needed to evaluate the effect and economic impact of the developed intervention that includes the return on the investment.