This generic selleck chemicals llc glucose-insulin dynamic model can be expected to develop such advanced therapy strategies for diabetics in the future. (C) 2010 Elsevier Ltd. All rights reserved.”
“In mammals, the olfactory sensory neurons are the only ones directly in contact with an aggressive environment. Thus, the olfactory mucosa is one of the few neuronal zones which are continuously renewed during adulthood. We have previously shown that endothelin is locally matured in the olfactory mucosa and
that olfactory sensory neurons preferentially express ET(B) receptors, while ET(A) receptors are rather present in non neuronal olfactory mucosa cells. In addition to its vasoactive effect, the endothelin system is known for its pleiotropic effects including the modulation of cell population dynamics. We thus examined its potential neuroprotective effect in the olfactory mucosa using a primary culture of olfactory sensory neurons lying on non neuronal cells. While a serum deprivation led to a massive decrease of the density of olfactory sensory neurons in the primary cultures, endothelin 1 (ET-1) rescued
part of the neuronal population through both ET(A) and ET(B) receptors. This effect was mainly anti-apoptotic as it reduced cleaved caspase-3 signal and nuclear condensation. Furthermore, Anlotinib concentration the olfactory epithelium of ET(B)-deficient rats displayed increased apoptosis. These results strongly suggest that ET-1 acts as an anti-apoptotic factor on olfactory sensory neurons, directly through ET(B) and indirectly by limiting non neuronal cells death through ET(A). (C) Alanine-glyoxylate transaminase 2011 IBRO. Published
by Elsevier Ltd. All rights reserved.”
“In this paper, we propose a simple method to analyze the similarity of biological sequences. By taking the average contents of biological sequences and their information entropies as the variables, the fuzzy method is used to cluster them. From the results of application, it finds that the method is relatively easy and rapid. Unlike other methods such as the graphical representation methods, which is usually very complex to compute some invariants of matric derived from graphical representation, our method pays more attention to the information of biological sequences themselves. Especially with the help of the software (SPSS), it seems to be very convenient. Therefore, it may be used to study the new biological sequences such as their evolution relationship and structures. (C) 2010 Elsevier Ltd. All rights reserved.”
“The medial prefrontal cortex (mPFC) is strongly involved in cognition and behavior. It receives input from brainstem nuclei implicated in behavioral wakefulness and electrographic cortical activation, such as the dorsal raphe nucleus (DRN). Moreover, the hypocretinergic/orexinergic (Hcrt/Ox) hypothalamic neurons innervate DRN, thus modulating its activity and presumably allowing transitions between sleep-wakefulness cycle states.