Additional data file 1 is a excel spreadsheet listing the 268 organisms used in this

study, and a table listing all orthologs obtain by the Bidirectional Best Hit. (XLSX 65 KB) Additional file 2: The following additional data are available with the online version of this paper. Additional data file 2 is a table listing PcoC proteins in 8 organisms harboring the full copper homeostasis repertoire, indicating location and presence of mobile elements. (XLS 14 KB) References 1. Crichton RR, Pierre JL: Old iron, young copper: from Mars to Venus. BioMetals 2001, 14:99–112.PubMedCrossRef 2. Gunther MR, Hanna PM, Mason drug discovery RP, Cohen MS: Hydroxyl radical formation from cuprous ion and hydrogen peroxide: A spin-trapping study. Arch Biochem Biophys 1995, 316:515–522.PubMedCrossRef 3. Macomber L, Rensing C, Imlay Veliparib concentration JA: Intracellular copper does not catalyze the formation of oxidative DNA damage in Escherichia coli . J Bact 2007, 189:1616–1626.PubMedCrossRef 4. Robinson NJ, Winge DR: Copper metallochaperones. Annu Rev Biochem 2010, 79:537–562.PubMedCrossRef 5. Pontel LB, Soncini FC: Alternative periplasmic copper resistance mechanisms in Gram negative bacteria. Mol

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