g , by precipitation 110-115 Indeed, high temperature processes,

g., by precipitation.110-115 Indeed, high temperature processes, e.g., plasma melting or sintering, would strongly reduce the specific surface area of the HA. As described in the previous paragraphs, the pore size distribution of spherical particles is of prime U0126 solubility importance for drug delivery. For orthopedic and dental applications, the focus is set on the space between the particles. Indeed, blood vessels and cells should be able to invade the inter-particular network to promote ceramic resorption and bone formation throughout the particle-filled defect. So, particles should be big enough to promote an easy blood vessel / bone ingrowth but not too large to keep an acceptable resorption time.133 Zhang et al.90 tried to estimate the size of the intergranular space based on the size of the spherical particles.

They came to the conclusion that values close to 1 to 2mm are ideal for orthopedic and dental applications. Use of Spherical CaP Particles Beside orthopedics and dentistry (Table 3), spherical CaP particles are used in very diverse fields of application such as food industry, pharmaceutics, o
Collagen is the most abundant protein in the body. It plays critical roles in many supporting and connecting tissues such as tendon, ligament, bone, blood vessels, skin, etc. Collagen gel prepared from commercially available collagen solution have been broadly used as a biomaterial in tissue engineering, drug delivery, and wound healing for its biocompatibility, low toxicity, and well-documented physical, chemical, and immunological properties.

1-3 Collagen gel is also used as three-dimensional model systems of extracellular matrix (ECM) in numerous studies of cell-ECM interactions under physiological and pathological conditions.4-7 Collagen thin film, or dehydrated collagen gel, has been used as a two-dimensional platform in a number of studies to examine cell-ECM interactions.8 As a biphasic material, collagen matrices contain a solid phase representing by collagen network and an interstitial fluid phase.9 This special structure makes collagen a viscoelastic material. The interstitial water can be assorted into two different types: tightly bound with collagen molecules and ��free�� or bulk like.10 The tightly bound water is believed to play an important role in stabilizing collagen structure by forming hydrogen bonds between collagen molecules and is not easily lost.

Entinostat The free water are the ones usually exchanges. The hierarchical structure of collagen, first unveiled by Kastelic et al.,11 is believed to be responsible for the necessary elastic strength and viscoelastic responses. Viscoelasticity is important for force/energy storage, transmission, and dissipation in biological tissues.12 To study the mechanical properties of collagen gel, direct measurements using uniaxial tensile testing,13-15 rheological method,16,17 dynamic mechanical analysis,18 and noninvasive microscopy approaches17,19,20 have been used in previous studies.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>