In Table 2b, univariate analysis shows that the odds of being bedfast or chairfast are significantly higher in the malnourished group compared to no risk Galunisertib cost of malnutrition. This means that malnourished LTC residents

are significant less active than residents in the no risk of malnutrition group. In Table 2c, univariate analysis shows that the odds of being a faller are significantly higher in the group that walks occasionally and in the group that walks frequently compared to bedfast. This means that LTC residents who walk occasionally or frequently are significantly more often a faller, and most in the group that walks occasionally. Significant differences in resident’s characteristics, i.c. gender, number of diseases, care dependency, physical activity, and BMI were checked for confounding by adding them sequentially into the multi varied model but none of them appeared to be an effect modificator. In Table 3, multivariate logistic regression analyses confirmed the relation between nutritional status and fallers but no effect-modification for activity was found (p = 0.222) indicating that the level of activity does not interfere with the relation between nutritional status

and fallers. Looking specifically Nivolumab at the active group, i.c. those LTC residents who walk occasionally or frequently, the relation between nutritional status and fallers was also not interfered by activity (no effect modification; p = 0.272). Multivariate logistic regression analysis shows no effect-modification of nutritional intervention on the relation between nutritional status and fallers in LTC residents at risk of malnutrition or malnourished (p = 0.277). This indicates that the relation between nutritional status and fallers is similar for those residents who received nutritional intervention and those who did not receive any nutritional intervention. However, looking at this relation in the group at risk of malnutrition and the malnourished group separately, Fig. 2 shows a lower rate of fallers, specifically in the malnourished group Bcl-w (OR 0.738, 95% CI: 0.541–1.007, p = 0.056). Although various

risk factors for falls have been identified, including muscle weakness and physical activity (AGS et al., 2001), an impaired nutritional status is seldom indicated as a risk factor. The present study therefore explored the relationship between nutritional status and fallers in elderly LTC residents. The secondary data analysis confirms that a relationship exists: the risk of being a faller is higher when there is an impaired nutritional status, and malnutrition can be considered as a determinant for being a faller in this population. Therefore our study provides further evidence for the increased propensity to fall with malnutrition, which was hypothesized in sparse previous publications (Daniels, 2002, Vellas et al., 1990 and Vellas et al., 1992).