“Methods: The computational model for each of the five ope


“Methods: The computational model for each of the five operating learn more modes offered by the generator is compared to independent tissue temperature measurements taken during in vitro ablation experiments performed on bovine myocardium.

Results: The results of the model agree with experimental temperature measurements very closely-the average values for mean error,

root mean square difference, and correlation coefficient were 1.9 degrees C, 13.3%, and 0.97, respectively. Lesions are shown to be contiguous and no significant edge effects are observed.

Conclusions: Both the in vitro and computational model results demonstrate that lesion depth decreases consistently SP600125 supplier as the bipolar-to-unipolar ratio increases-suggesting a clinical application to potentially control lesion depth with higher fidelity than is currently available. The effect of variable design parameters and clinical conditions on RF ablation can now be expeditiously studied with this validated model. (PACE 2010; 33:1089-1100).”
“Time

trade-off (TTO) exercises typically present respondents with a limited time horizon, for example 10 years, thus implicitly considerably reducing remaining life expectancy for the average respondent. It is unclear how this affects health state valuations.

The aim of the study is to investigate Selleckchem CP690550 how awareness of the reduced life span implied by a 10-year TTO affects health state valuations, using an experimental design.

Two Web-based questionnaires (Q1 and Q2) were administered in a sample representative of the Dutch population. Both questionnaires contained three 10-year TTO exercises valuing three distinct health states,

specified using the EQ-5D. Q1 used a TTO instruction not explicitly emphasizing the fact that remaining life expectancy was reduced to 10 years, while in Q2 respondents were explicitly made aware of this fact by emphasizing their implied age of death. Respondents answering Q1 were asked retrospectively whether they had been aware of their reduced life span due to the 10-year TTO.

In total, 656 respondents completed the questionnaires (Q1: 339 and Q2: 317). The average age of the respondents was 43 years and 51 % of respondents were male. The average numbers of years traded off for the respondents of Q1 were for TTO1 0.443, TTO2 0.552, and TTO3 2.083 years. For the respondents of Q2, these averages were lower, i.e., TTO1 0.401 (p = 0.085 vs. Q1), TTO2: 0.546 (p = 0.036 vs. Q1), and TTO3: 1.467 years (p = 0.000 vs. Q1). Fifty-seven percent of respondents in Q1 confirmed that they were aware of the reduced life span. This spontaneous awareness had a limited and mixed influence on results.

Comments are closed.