Supplementary Material Author’s manuscript: Click selleck chem Tipifarnib here to view.(2.3M, pdf) Reviewer comments: Click here to view.(245K, pdf) Acknowledgments The authors thank the organisations (Waverly Care, Terrence Higgins Trust Scotland, LGBT Youth Scotland, Gay Men’s Health Scotland,

Positive Scotland, NHS Greater Glasgow and Clyde, NHS Lothian, NHS Grampian) who helped with recruitment and the men and women who agreed to take part in the focus groups and interviews. Footnotes Contributions: IY designed the study, carried out the qualitative data collection and analysis and drafted the manuscript. PF helped to design the study, carried out some of the data collection and analysis and helped to draft the manuscript. LMD participated in the design of the study and helped to draft the manuscript. All authors read and approved the final manuscript. Funding: The HIV and the Biomedical Study, IY and LMD are core funded by the UK Medical Research Council (MRC) (MC_U130031238/MC_UU_12017/2) at the MRC/Chief Scientist Office (CSO) Social and Public Health Sciences Unit, University of Glasgow. PF is funded by Glasgow Caledonian University.

Competing interests: None. Patient consent: Obtained. Ethics approval: College of Social Sciences Ethics Committee, University of Glasgow (CSS2012/0193, CSS20120264). Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: This study was undertaken by the MRC/CSO Social and Public Health Sciences Unit, University of Glasgow. Our data sharing policies comply with that of the UK Medical Research Council. Unpublished data from this study is available on request and information about the study and data is made available on the MRC/CSO Social and Public Health Sciences website. https://www.sphsu.mrc.ac.uk/research-programmes/sh/shfsub/accbiomhivprev.html.
The analysed parameters were not normally distributed (p<0.05), therefore we trusted the Spearman correlation analysis. CRP showed significant correlations with MPV (ρ=0.088, p=0.045), NLR (ρ=0.4, p<0.001) and ESR (ρ=0.468, p<0.001) in patients

with cerebral infarction (figure 1). However, MPV/PC (ρ=0.016, p=0.711) AV-951 was not significantly correlated with CRP in patients with cerebral infarction. In the male group (n=291), CRP showed significant correlations with NLR (ρ=0.398, p<0.001), and ESR (ρ=0.502, p<0.001) in patients with cerebral infarction. However, MPV (ρ=0.008, p=0.890) and MPV/PC (ρ=−0.077, p=0.188) were not significantly correlated with CRP in the male group. In the female group (n=225), CRP showed significant correlations with MPV (ρ=0.17, p=0.011), NLR (ρ=0.392, p<0.001) and ESR (ρ=0.475, p<0.001) in patients with cerebral infarction. However, MPV/PC was not significantly correlated with CRP (ρ=0.104, p=0.121) in the female group.