While it is possible to perform early surgery for stable patients, surgery should be performed in patients with complex co-morbidities once they are optimized. On the other hand, the condition of unstable patients should be better optimized before surgery is contemplated. It requires a common understanding of the different disciplines of health care personnel to work towards this goal. Protocols and guidelines would help doctors and the patients in the decision-making process Temsirolimus as when surgery can be safely done. The Scottish Intercollegiate Guidelines

Network suggest that medically fit patients should receive surgery as soon as possible, within safe operating hours, after presenting to hospital [47]. The British Orthopedic Association guidelines also state that surgical fixation should not be delayed for more than 48 h from admission unless there are clearly reversible medical conditions [48]. The Royal mTOR inhibitor College of Physicians recommends that for patients with hip fracture operations should

be carried out within 24 h, by senior staff [49]. As a result, some hospitals, governments, and administrators have set this as a target, making hip fracture as a performance indicator in the quality of healthcare delivery. Conclusion Although there is no solid evidence that early surgery would improve mortality, there is widespread evidence in the literature that other outcomes including morbidity, the incidence of pressure sores, and the length of hospital stay could be improved by shortening the waiting time of hip fracture surgery. Early surgery can also bring better pain relief. Hence, it is still advisable for surgeons to treat these patients as soon as their Exoribonuclease bodies meet the basic anesthetic requirements. This timing may vary from individual patient and would not be identical. Disagreement exists even among doctors from different medical specialties. However, setting a goal of surgery within 24 h by hospital and administration would greatly help

to bring together the team to provide a timely and effective treatment to these patients. Acknowledgment The research and preparation related to this paper is supported by a research grant from AO Foundation. Conflicts of interest Dr. Leung is the speaker for Synthes and has received research support from Synthes. The other authors declare no conflicts of interest. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References 1. Hornby R, Evans JG, Vardon V (1989) Operative or conservative treatment for trochanteric fractures of the femur. A randomized epidemiological trial in elderly patients. J Bone Joint Surg Br 71:619–623PubMed 2.